For Wine, you can mostly just stick to whichever you prefer out of Lutris or Heroic Game Launcher, and it will require little to no tinkering. I don’t mod often, but the ones that allow you to just extract files to a directory have all just worked for me so far. Heroic has a feature where you can run another EXE, like a config tool or a mod in this case, in a given game’s Wine prefix (environment/settings).
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For Wine, you can mostly just stick to whichever you prefer out of Lutris or Heroic Game Launcher, and it will require little to no tinkering. I don’t mod often, but the ones that allow you to just extract files to a directory have all just worked for me so far. Heroic has a feature where you can run another EXE, like a config tool or a mod in this case, in a given game’s Wine prefix (environment/settings).