I have homozygous C677T mutations in my MTHFR gene, with homozygous COMT mutations further limiting neurotransmitter regulation. I feel very different when consuming foods high in activated folates, or related vitamins/supplements.

For B vitamins, you’ll probably just pee out any excess, so likely you’re just making really expensive pee unless you have a vitamin deficiency.

For the D,E,K,A vitamins, they can actually be problematic if consumed in too high of quantity over a long period of time, due to the fact that they are fat soluble and can build up and cause organ damage.

Of course, that’s only if you’re consuming far in excess of the necessary vitamins for a long period of time. Otherwise just like water soluble vitamins, your body just ditches anything over a useful amount.

Some vitamins that are hard to get otherwise are fortified into common staple foods, especially in developing countries, but with a healthy, balanced, modern diet, you’re probably getting what you need from your food. Unless you have a vitamin absorbing issue, other medical issue, or a lack of food variety.

Tbh I had folate deficiency anaemia for a long time. It’s not fun.

All depends on if you’re deficient. If your levels are normal, it may not have much effect. But, according to the NIH, “Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function [1,2]. Individuals with borderline vitamin B6 concentrations or mild deficiency might have no deficiency signs or symptoms for months or even years. In infants, vitamin B6 deficiency causes irritability, abnormally acute hearing, and convulsive seizures [2].” If this is you, you might just feel a whole lot better.