They pulled Vioxx from the market, when it’s cardiovascular safety profile is actually quite similar to other NSAID’s and Tylenol. Tylenol can actually have a lot of long-term adverse effects (kidney damage, liver damage, blood pressure, ulcers, cardiovascular risk, and blood cancer), but these drugs are still on the market mostly on the understanding that you’ll use them infrequently and at low doses.
Opioids generally don’t have any long-term adverse affects, the risks are just addiction, overdose, and unconscious vomiting (not problems once you’re successfully got off opioids). If your doctor is competent, fentanyl will indeed be safer for you. There’s a reason it’s used so commonly in hospitals and other medical settings. Fentanyl even has euphoria more mild than most other opioids, so it’s generally not where addiction starts.
You’re downplaying fentanyl’s and overplaying Tylenol’s problems here. For example, the latter’s hepatic toxicity happens in the case of an overdose (usually intentional), and most cases are self-limited. There’s also a widely available antidote.
Overdosing on fentanyl is much more likely with “correct” use, and it will also most likely kill you due to respiratory depression. It also has very relevant and common adverse effects, like hyperalgesia (making the pain worse).
There’s a reason it’s used so commonly in hospitals and other medical settings. Fentanyl even has euphoria more mild than most other opioids, so it’s generally not where addiction starts.
Hospital use for over 2 days is widely unencouraged due to withdrawal syndrome (plus quickly inducing resistance and hyperalgesia, demanding higher doses), and we’ve been trying to develop ways of reducing its use for the past 10 years or so. Check out PADIS 2018
Yeah Tylenol is a trash med that would never get approved today, especially not OTC. Unfortunately it’s one of the only things they let pregnant women take for pain. We need more research into the opiate drugs, there are atypical mu agonists that actually don’t carry as much addiction and overdose risk (gee I wonder why these didn’t get discovered when they were looking for a replacement for heroin/morphine), kappa antagonism might be useful in chronic pain, and delta agonists seems promising as well.
Opioid pharma companies were a big cause of the opioid epidemic no doubt, but the government response is what’s made it so dire. They just cut a whole bunch of peoples safe opioid supplies, so people could either go into withdrawal, or start using non-pharma drugs. Letting pharma opioids continue what they were doing probably would have, funnily enough, saved many peoples lives.
Over-prescribing painkillers wouldn’t be great, but it won’t turn catastrophic until someone tries to do a drug crackdown. There’s also been a lot of successful anti-opioid propaganda, to the point where I’ve had friends decide to just bear through the pain rather than accept a 5m oxycodone from the doctor.
I doubt that Tylenol has anything to do with Autism, though. It seems extremely unlikely. And there’s still plenty of non-opioid painkillers left after they get rid of Tylenol, Tylenol is just the common one because it’s side effects aren’t terrible.
They pulled Vioxx from the market, when it’s cardiovascular safety profile is actually quite similar to other NSAID’s and Tylenol. Tylenol can actually have a lot of long-term adverse effects (kidney damage, liver damage, blood pressure, ulcers, cardiovascular risk, and blood cancer), but these drugs are still on the market mostly on the understanding that you’ll use them infrequently and at low doses.
Opioids generally don’t have any long-term adverse affects, the risks are just addiction, overdose, and unconscious vomiting (not problems once you’re successfully got off opioids). If your doctor is competent, fentanyl will indeed be safer for you. There’s a reason it’s used so commonly in hospitals and other medical settings. Fentanyl even has euphoria more mild than most other opioids, so it’s generally not where addiction starts.
You’re downplaying fentanyl’s and overplaying Tylenol’s problems here. For example, the latter’s hepatic toxicity happens in the case of an overdose (usually intentional), and most cases are self-limited. There’s also a widely available antidote.
Overdosing on fentanyl is much more likely with “correct” use, and it will also most likely kill you due to respiratory depression. It also has very relevant and common adverse effects, like hyperalgesia (making the pain worse).
Hospital use for over 2 days is widely unencouraged due to withdrawal syndrome (plus quickly inducing resistance and hyperalgesia, demanding higher doses), and we’ve been trying to develop ways of reducing its use for the past 10 years or so. Check out PADIS 2018
Respiratory depression long term can have severe effects on the brain and body, don’t fuck with opioids.
Yeah Tylenol is a trash med that would never get approved today, especially not OTC. Unfortunately it’s one of the only things they let pregnant women take for pain. We need more research into the opiate drugs, there are atypical mu agonists that actually don’t carry as much addiction and overdose risk (gee I wonder why these didn’t get discovered when they were looking for a replacement for heroin/morphine), kappa antagonism might be useful in chronic pain, and delta agonists seems promising as well.
Opioid pharma companies were a big cause of the opioid epidemic no doubt, but the government response is what’s made it so dire. They just cut a whole bunch of peoples safe opioid supplies, so people could either go into withdrawal, or start using non-pharma drugs. Letting pharma opioids continue what they were doing probably would have, funnily enough, saved many peoples lives.
Over-prescribing painkillers wouldn’t be great, but it won’t turn catastrophic until someone tries to do a drug crackdown. There’s also been a lot of successful anti-opioid propaganda, to the point where I’ve had friends decide to just bear through the pain rather than accept a 5m oxycodone from the doctor.
I doubt that Tylenol has anything to do with Autism, though. It seems extremely unlikely. And there’s still plenty of non-opioid painkillers left after they get rid of Tylenol, Tylenol is just the common one because it’s side effects aren’t terrible.