Bazzite would be my suggestion. Throw the full install on the ssd then format the HDD for general storage. I’d be a little concerned about the 1060 3GB GPU though. Drivers will likely be fine, but the “10 series” have notoriously awful async compute and take a much larger penalty when running games/apps under proton/vulkan if I recall correctly.
Notice how all the newer and “ultimate” controller series are missing. They have some support, but overall it’s still pretty lacking.
Mine “hangs” for a while but does EVENTUALLY boot. It takes like 3-5 minutes though which is very unusual. It used to boot in a few seconds (nvme ssd boot drive), so at first I was worried maybe the drive was going bad.
Now we just need their software and firmware updates to run in Linux native (or even wine, I’m not that picky). Excellent controllers for the cost.
The bazzite project website has an explicit “how-to” for extra drives. Worked for me with no issues, though I am definitely more experienced with tinkering with that kind of thing.