• RealSpiderLane@lemmy.zip
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      6 hours ago

      Ex alcoholic and “cirrhosis survivor” here. (I hate that latter term.)

      I’m stunned that this situation went down how it did.

      I had the full jaundice package when I finally went into the hospital and agreed to detox. I was told I would have to be booze-free for a minimum of six months to be considered for a transplant of any kind; both my liver and kidneys were in concerning shape.

      They told me the timeframe for actually being considered was more like two years; there’s basically a board of trustees for each state, they review every case requesting an organ transplant and decide who gets what. (It’s literally a death panel, haha.)

      No matter how good I was/am, I would still be at the very lowest priority. They’d have to have available livers as far as the eye can see for me to have a realistic chance. There is no actual chance I would ever get a donor liver, and I don’t want one.

      I was dumb. I did it completely to myself. It’s not as simple as “you could’ve quit anytime you wanted,” trying to do that with alcohol is extraordinarily dangerous, BUT I did indeed do this to myself. It would be galactic levels of unethical and immoral for me to be trying to take a donor liver away from ANYONE.

      I have since recovered way past the expectations of any medical personnel who worked on me during that time. July 1 will be two years alcohol-free for me.

      My point in all of this is that I’m honestly having trouble believing this guy got this transplant at all, let alone so fast.

    • Bgugi@lemmy.world
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      7 hours ago

      Organs don’t keep… If they got the donor it probably meant there wasn’t anybody else queued up.

  • BoxOfFeet@lemmy.world
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    1 day ago

    I think what’s extra dangerous about Tylenol is that it doesnt feel like it’s doing anything. When it works, some minor pain goes away, or maybe your fever goes down. But there’s no side effects that you really feel, so I bet people get a false sense of security with it. Like, oh it isn’t giving me opioid euphoria, or knocking me out. And you can just buy as much as you want, no restrictions. It must be perfectly safe.

    • HEXN3T@lemmy.blahaj.zone
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      10 minutes ago

      I think Tylenol being barely perceptible is why I’ll always feel safer with opioids, THC, or even NMDA antagonists like ketamine in a pinch–as someone who is extremely informed with this particular subject.

      I blame autism.

      If a compound is barely effective, causes liver damage (particularly with other compounds metabolised in the liver), and has a bunch of negative interactions… sorry, it’s garbage. I genuinely would rather go darknet than CVS or Walgreens, and test for purity. Besides, dealers are generally way cooler than corpos anyway.

      I hope that nobody takes it as an invitation, though–I said I’m informed. If you’re not informed, don’t.

      I will add this; Tylenol? Almost placebo. Phenylephrine? Actually placebo. Guaifenesin? Placebo if taken orally. Practically the entire counter is placebo, except for the antihistamines (first/second generation like diphenhydramine/Benadryl and cetirizine/Zyrtec) and nasal cleaners and such. With that in mind, I would encourage people to research absolutely everything they ingest, regardless of how safe the product may seem.

      They are certainly not 100% safe.

      This should go without saying (probably preaching to a choir), but legal ≠ safe, indeed. Still waiting on that thesaurus to prove me wrong. It’s been 3 years.

      Stay smart, and stay safe.

    • kkj@lemmy.dbzer0.com
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      19 hours ago

      Nothing is perfectly safe. You can kill yourself with water poisoning, and that’s pumped directly into your house.

  • Shardikprime@lemmy.world
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    My brother in Christ, the paracetamol box LITERALLY says to never go more than 4 grams (4000 mg) in a 24hs period on any mg pills presentation

    And as far as I see, that’s a general rule with everything. Even those caramels for sore throat or reflux pills, where you’d need to eat thousands in a day to overdose, say the same

    Don’t fuck with medicine dudes

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        The only way it happened is if people who need a liver but not because of alcohol-related damage are pushed to the top of the list. The alcoholics would basically be last in line. Some might say that’s discriminatory, but it’s perfectly normal to triage patients and provide care to the ones with more immediate needs, or the ones most likely to survive. Doctors have to make judgement calls.

    • Rhonda Sandtits@lemmy.sdf.org
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      Or even need a liver transplant in this situation.

      The liver heals itself so removing the paracetamol that caused the failure would allow the liver to begin that healing process.

      • SirQuack@feddit.nl
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        Four packs of Paracetamol will fuck up your liver beyond repair. Downing a blisterpack in one go can already kill you, let alone four.

        • TRock@feddit.dk
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          It wasn’t even 4 packs, it was at least 12 packs, probably a bit more. Also how many are in a pack?

      • mastertigurius@lemmy.world
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        No organ magically heals itself, you’re not Wolverine. Liver damage is permanent, any dosage over 4 grams of paracetamol per 24 hours (typically four doses of two 500mg tablets) can cause liver damage. Let the damage accumulate, and you’ll go into liver failure. If the liver fails, you’ll have to hope you’re lucky enough to get a donor, or you’ll be counting down hours left in your life. Take good care of your body and be healthy, your older self will thank you.

        • prole@lemmy.blahaj.zone
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          No organ magically heals itself, you’re not Wolverine.

          Why would it be magic? My skin heals itself. Bones heal themselves…

        • Rhonda Sandtits@lemmy.sdf.org
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          No organ magically heals itself, you’re not Wolverine

          There are at least 2 organs that heal. First is your skin, if you consider that an organ. Wounds heal and often leave scars as a lasting reminder of the damage that was there.

          The other organ is the liver, the scar tissue that occurs in the liver after healing is called cirrhosis.

          • wewbull@feddit.uk
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            Time is the factor you’re missing.

            When the liver is damaged it stops doing it’s function. Removing the paracetamol doesn’t remove the damage, so the the liver is still not functioning. It would take a long time to recover the liver function after you’ve stopped taking the paracetamol. You can only live days without a functioning liver.

            Hence, you’re dead.

  • RBWells@lemmy.world
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    Not “even paracetamol”. ESPECIALLY paracetamol.

    Tylenol/acetaminophen/paracetamol is both weak ass painkiller and really dangerous because the overdose line is low. Here they put it in synthetic opioid drugs, it doesn’t help with pain but does make them more dangerous.

    • QuoVadisHomines@sh.itjust.works
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      Opioids are fir suffering whereas acetaminophen is for pain signals. A combination of ibuprofen and acetaminophen have been demonstrated to be the most effective pain killer we currently have.

      Pain and suffering are different things.

    • prole@lemmy.blahaj.zone
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      It might not get you high, but it absolutely does help actual pain when combined with opioids.

    • Ledericas@lemm.ee
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      oh yea it isnt as good as other otc nsaids, like ibuprofen and naproxen, or aspirin. oh and that fake pseudoephedrine mimic(phenyleprine) for cogestion, they already said it has no effect whatsoever. its mostly the 1st generation antihistamines doing all the work for your sinuses when you have the cold anyways.

      • wewbull@feddit.uk
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        isnt as good as other otc nsaids, like ibuprofen and naproxen, or aspirin

        The do different things. It all depends on the type of “pain”.

  • douglasg14b@lemmy.world
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    Sounds like American healthcare to me.

    You either cope, and probably cause irreparable hard to yourself, or you go to the clinic or ER and get labeled a drug seeker.

      • BoxOfFeet@lemmy.world
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        Oh, shit! Guy OD’d on acetaminophen? Yeah, that is scary. My wife had a friend that attempted a self KO with Tylenol for some reason. What a horrible way to go. She is so lucky she didn’t need a transplant.

    • GreenKnight23@lemmy.world
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      fun fact, when you mix sinus medicines your blood can test positive for methamphetamine.

      I know this because I am now on a list of meth addicts at every networked hospital after an er visit while treating a sinus infection.

      they took four blood tests and “confirmed” I was high on meth and refused to treat why I was there in the first place because to them, I was high as shit. even though I was literally directing people around blood on the floor and calling for housekeeping to come clean up the blood on the floor because the nurse refused to do her fucking job.

      I asked to be removed from the list as well as have the false test results removed from my history and was told that’s impossible.

      doesn’t technology make things so much better? Now the best pain meds I’ll ever get at a hospital will be extra strength Tylenol. you know, that shit I have at home they charge me $400 a pill for.

      • ouRKaoS@lemmy.today
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        20 hours ago

        Pseudoephedrine is the main ingredient in meth, that’s why they changed all the OTC sinus stuff to phenylephrine years ago, and why the OTC stuff doesn’t work worth a damn anymore.

  • ColeSloth@discuss.tchncs.de
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    He’s lucky it was just his liver. People who overdose or try to commit suicide with it are not in for a good time or quick death and after it’s absorbed into your body it will cause a systemic shutdown of several organs like the kidneys and pancreas. Not just the liver, and there’s absolutely no way to counteract this after that first 36 hours. You will die (you aren’t getting all of the organs replaced) and it will take days before you succumb. No antidote or life support or anything can be done for you.

    You’ll feel fine the first day but may have some vomiting. By day 3 the jaundice and stomach pain sets in as the liver is first to show signs of the organs failure and it’s no longer possible to counteract the drug. By the fourth day your organs start shutting down and you’ll have much more pain and vomiting. All that can be done is get your affairs in order because you’ll be dead and in pain while you wait around to die and regret your suicide.

    I say suicide because it’s almost always intentional. It usually takes 40 325mg pills to cause this, although the liver damage can be caused with 20+ pills in an adult, generally. If you think you’ve possibly overdosed get to the hospital quick and tell them what you’ve taken so they can start you on Acytylcystine. If you “feel fine” after the first day or so and think you’re all good you may be wrong and when day Tyree rolls around and your feeling bad or jaundiced your liver is already wrecked and can’t be fixed.

  • ShankShill@sh.itjust.works
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    My daughter’s dog that is a climber got on a shelf and knocked a basket off that had a large bottle of Tylenol in it. She chewed the bottle up.

    I got home and saw some pills and a demolished bottle on the ground. Vet tech friend said to induce vomiting with hydrogen peroxide.

    Didn’t have any of that, but I did have some minty mouthwash with peroxide and no xylitol in it. Dog willingly drank it, puked with foam, drank a bit more, puked more foam, then I dug through the mess.

    No pills or any sign of the color on the pills. She’s still kicking.

    • GreenKnight23@lemmy.world
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      induce vomiting with hydrogen peroxide.

      Didn’t have any of that

      how are you alive? H2O2 is like the basic necessity of every first aid kit. when you get a cut or scrape at home do you just like, ignore it?

      do you even have bandaids or triple antibiotic ointment?

      • beastlykings@sh.itjust.works
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        As far as I understand it, you shouldn’t put peroxide on most, or maybe even any, wounds. It indiscriminately kills good and bad bacteria as well as your body’s cells. So it can make the wound take much longer to heal.

        Similar, but I think different, with iodine. You shouldn’t use it in most cases.

        The recommendation is to use warm soapy water to rinse/clean the wound really good. That’s all.

        If the wound is deep enough or gnarly enough that this doesn’t seem reasonable? Well, peroxide wasn’t gonna help you anyway, go to the doctor.

        I’m happy to be wrong here, to be corrected. But this is how I understand it.

        Also I do keep peroxide in my cupboard, as well as rubbing alcohol. Their uses just aren’t for wounds.

      • babboa@lemmy.world
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        Peroxide is actually a pretty terrible wound cleanser. Does as much damage to the healing tissue as to any bacteria, which is why you seldom see it used in the hospital. Honestly you are better off with lots of clean warm water and mild soap. If you really want to get wild, find some true antibacterial soap with chlorhexidine (hibiclens is the big brand name in the US) and wash the wound with that. Just don’t use it on the face bc it’s really bad for the eyes.

        • GreenKnight23@lemmy.world
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          I guess.

          I grew up on a farm. every cut, stab, or scrape was done on some rusty, shit caked, dirty metal thing or some sharp blade covered in blood. so peroxide was always used because the risk of some bacteria left behind for infection was greater than the risk of scar tissue.

          my wounds heal pretty quickly, so it’s not something I’ve had to deal with.

          • babboa@lemmy.world
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            Just because we do something for a long time doesn’t mean it’s the right thing to do. In most cases, forceful irrigation with sterile saline is the best way to handle a dirty wound.

  • Flamekebab@piefed.social
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    It’s bizarre to me that someone can make it to adulthood without knowing that paracetamol specifically is no fucking joke.

    • Raltoid@lemmy.world
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      People look up resources on them and see that the recommended max dose of ibuprofen is lower than paracetamol per day in weight of the active ingredient and stop reading.

      They don’t get to the part about how the effect per weight isn’t the same. Or how damaging paracetamol can be for the liver if you take it regularly or go over the recommend limit. Heavy drinkers especially don’t take into account the extra stress on their liver, which is a contributor to the 400-500 deaths it causes every year in the US alone.

      Meanwhile ibuprofen makes you feel sick and want to vomit once you start to go over the recommended limit. And if you reach that stage, you basically just stay hydrated to keep your kidneys going and wait for it to pass. Since it usually takes another 2-3 times as much to for the severe effects to occur.


      To quote Scrubs:

      Dr. Cox: Did you just page me to ask me how much ibuprofen to give Mrs. Lenzner here?

      Sunny: Well, I was worried it would exacerbate the patient’s

      Dr. Cox: It’s ibuprofen! Here’s what you do. When she wakes up, get her to open her mouth nice and wide, then get some of those ibuprofen pills in your hands and throw them at her. Whatever sticks in there, that’s the correct dosage.

    • markovs_gun@lemmy.world
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      I would say most people are like this. Knowing it’s super dangerous in high doses is the minority because it’s sold OTC and everyone knows and trusts it.

    • Dozzi92@lemmy.world
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      Acetaminophen (paracetamol) is definitely tough on the liver. I remember during EMT classes (well, I kinda remember, was 20 years ago) having one of the paramedics in the class talking about how it was worse on the liver than heroin. Now yes, heroin obviously has other downsides, but it’s just crazy to think about. I have always limited my intake of it, never take it if I’ve been drinking, that sort of thing. The issue is that it’s not exactly common knowledge. I know plenty of people who would drink and take some Tylenol at bedtime to kill the hangover. Not a good habit.

        • Kiernian@lemmy.world
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          Not in the US.

          On an informal survey of several hundred men aged 18 to 60 at or below the income cutoff for recieving free medical insurance from the state they were living in, less than 10% knew Tylenol was bad for your liver at all and just over 25% knew that long term ibuprofen use was bad for kidneys.

          The number goes up when income does, but considering the number of people working for minimum wage over here…

          We have a culture of ADVERTISING medication here, every possible attempt at minimizing public knowledge of medical side effects is made at every legal turn because fear cuts profits.

          Edit – I should add that I’ve met multiple educated people who heard that the Brits had some super dangerous liver killing over the counter painkiller that they just LET people have who were glad we didn’t allow that kind of nonsense here.

          Very few people know what paracetamol is and would be surprised to learn it’s another name for Tylenol.

        • starman2112@sh.itjust.works
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          It’s common knowledge, in the same way that “you shouldn’t text and drive” is common knowledge. People know it, and ignore it

      • Crankenstein@lemmy.world
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        there is a stark difference between “studies drugs” and “does the bare minimum research on the pharmaceuticals one puts into their body”

        • starman2112@sh.itjust.works
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          I was about to make a joke about understanding the safety profile of the air you breathe, and then I remembered I work near various chemicals… Mfs have mixed clorox and lysol at my workplace before. Safety is no joke

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        I was taught this as an actual child because it’s so important and paracetamol is so common. It’s nothing to do with “studying drugs”.

    • juliebean@lemm.ee
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      according to the acetaminophen i’ve got at home, dangerous dosage is >4g per day. that means that if 4 packets was 20x that, each packet would be 20g, which, if they’re normal 500mg pills, would be 40 pills per packet.

      • ragebutt@lemmy.dbzer0.com
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        you should stick to 3g a day if you’re overall a small person, some bottles will recommend this as the max to be safe

        • Darrell_Winfield@lemmy.world
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          Therapeutic dose of acetaminophen is 15 mg/kg q6h prn. That dose of 4g/day ==> 1g/dose. 1000mg/(15mg/kg) = 66.67kg == 145lb.

          That’s the minimum weight for that acetaminophen dosing. If you’re under that weight, you can consider the reduced dose. If you’re over 145lb, no need to worry. And honestly, I think I’m the only one who actually doses this stuff q6h anyway. I think most people end up doing TID dosing because that allows uninterrupted sleep.

    • Ephera@lemmy.ml
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      Various countries limit painkillers to small packet sizes (e.g. 20 pills here in Germany) and pharmacies only hand them out one at a time, so you can’t overdose as easily/spontaneously, either like the person in the post did due to pain, or for suicidal purposes.
      It’s not perfect protection, as you can just go to multiple pharmacies to buy multiple packets, but yeah, you will have to actually go do that and will get told at the pharmacy that you shouldn’t take more, if you’re not aware.

      • Duranie@leminal.space
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        Yikes! The use of the term “packet” was initially confusing to me. Here in the States it’s not uncommon to see small packets of a single dose of over the counter medicines in gas stations and convenience stores for when you’re not at home and something comes up. The directions for extra strength Tylenol are 2 every 6hrs (1000mg dose) not exceeding 3 doses per day.

        I was thinking “4 packets over 3 days, what’s the big deal?”

          • Ledericas@lemm.ee
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            i heard some people fitness takes these so they can train excessively longer than normal. it was a news article a certain group was discussing, and they were tellinig a story of a dude doing that, that guy got addicted for sure to the pain meds, because they said he couldnt do anything without them.

        • Ledericas@lemm.ee
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          they sell blister packs for tyelenol, but its usually thr brand name, which is pretty expensive.

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        America… I remember seeing “value packs” of Tylenol containing 300 pills… that’s their idea of freedom… to allow people the choice of slow and agonizing suicide by liver failure

          • prettybunnys@sh.itjust.works
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            Exactly, I know I can take 2 a day and a couple days and if the pain persists I ought to seek out medical help.

            We know how to follow directions, we’re just not fucking gonna

        • Ledericas@lemm.ee
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          kids were trying to robotrip on dextrotomorphan, and now they require ID to buy any cold medicine that contains it.

        • orbitz@lemmy.ca
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          The bottle on my shelf has 350 (new, Costco brand) but I don’t take over the recommended dose for obvious reasons. Guess it expired last year now that I look heh. The smaller bottles cost more per dose so no reason not buy a larger one. This is in Canada, not the US for people curious about other countries.

          • LemmyFeed@lemmy.dbzer0.com
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            That math doesn’t quite add up. Sure less per dose sounds good, but if you’re wasting half the bottle then paying a little more per dose but less total cost is still more economical.

            • Ledericas@lemm.ee
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              i buy the larger ones online. better than buying the small ones. i do this for anti-histamines too, because i got allergies, i can get 1000tablets for the 1st generations easy, and cheaper pricing for the 2nd generation ones years worth. kirkland has the quality to it, im trying some off-brand(probably chinese made) doesnt seem as effective, and it was a wierd shape.

            • orbitz@lemmy.ca
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              It may be less effective but you use it till the bottle is done, it’s not like milk it still works.

          • Ledericas@lemm.ee
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            they sell larger bulk bottles, usually i buy them on amazon, in-stores are usually more expensive. i also use naproxen too.

    • GreatAlbatross@feddit.uk
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      Depends on the country I guess.

      Here, a packet is 16 tablets of 500mg (acetaminophen) or 200mg (ibuprofen).

      We’re limited to 2 packets combined per purchase to reduce the chances of severe overdose.

      Package dosing generally suggests 2 tablets per dose, with at least 4 hours between.
      Or one tablet for children between 10 and 14.

    • SolOrion@sh.itjust.works
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      Well, generally you’re only supposed to take ~2 tablets at a time, so 10? 40 pills a day is 13,000mg of acetaminophen, or 20,000mg if they’re extra strength.

      That’s, uh, bad. You’re recommended to take under 4000mg per day, so that’d be a bit over a packet? Makes sense to me.

      For the record, mixing two painkillers without consulting a doctor is also usually a bad idea but way fucking less of a bad idea than taking 13000mg of tylenol in a day. Afaik, acetaminophen with other stuff is probably fine but napoxen, ibuprofen, and aspirin all work roughly the same way and shouldn’t be mixed.

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        For the record, mixing two painkillers without consulting a doctor is also usually a bad idea but way fucking less of a bad idea than taking 13000mg of tylenol in a day.

        Basically, if something hurts so much that you might take enough paracetamol/acetaminophen to fuck with your liver then you yes, you should be under a doctor’s care. That said, between my wife and me, we’ve had three or four doctors over the years all be very chill with the idea of alternating Tylenol and Ibuprofen after surgery or the like. I guess they work on such different chemical pathways that they don’t have much interaction potential, and keeping under the daily dose of Tylenol in particular is incredibly important, as we’ve seen in this thread.

        • SolOrion@sh.itjust.works
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          yes, you should be under a doctor’s care.

          That’s not always an option, unfortunately, but it’s definitely accurate.

        • peoplebeproblems@midwest.social
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          They act on different systems, yes, but this is more about the metabolism of each.

          Non-steroidal-anti-inflamatorirs can cause damage to your stomach and kidneys.

          Acetaminophen/Paracetol metabolizes in the liver a similar way alcohol does, and like alcohol has a maximum rate of clearing the toxin.

        • Ledericas@lemm.ee
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          tyelonol works on the liver, the others like ibuprofen, naproxen,etc works by inhibiting the cox1 and 2 enzymes. of courses take 2 much of the inhibitors is very similar to aspirin, it can prevent clotting(which in itself is a therapeuthic uses for clotting disorders)

      • Korhaka@sopuli.xyz
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        Don’t take my word for it but I think paracetamol and ibuprofen with added codeine can be taken together despite the double codeine as the amount they have is low enough that double is still safe.

        Check with a pharmacist first, dosages are going to vary and I am just some guy on the internet.

    • GissaMittJobb@lemmy.ml
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      I don’t think there’s a standard size, but I know they sell them in packages of 3x10 where I live. Eating 4 full packets of those in a day would put you at 15 times the upper recommended daily dosage, for what it’s worth, which is calculated slightly conservatively to not be lethal for any adults

        • Ledericas@lemm.ee
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          the ones for arthiritis, is around 625mg, with caffiene. i had 500mg naproxen Rx for buristis once, it can cause stomach issues, because it turns on inflammation, so the acid levels increase and can cause things like heartburns.

  • 𝕽𝖚𝖆𝖎𝖉𝖍𝖗𝖎𝖌𝖍@midwest.social
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    You know what else is stupid? Pain management in the US. I get that you need to be careful about addiction, but the idea that people should have to suffer pain because we’re having a pain medication “reefer madness” spasm is idiocy.

    The guy just kept taking them until his teeth stopped hurting. Why is the alternative that he just has to put up with being in pain?

    • sulgoth@lemmy.world
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      The fact that the drug companies lied about the addictiveness of their product so doctors were handing them out like candy didn’t help.

      • Dozzi92@lemmy.world
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        Yeah, it was rampant here in Jersey, and we’re definitely still feeling the effects. Things that didn’t need opiates got opiates. And guess what? Lotta people all of a sudden need them for life. And it wasn’t just Oh, here’s your script. Doctors were knowingly abusing it for profit. So like with most things in life, some people ruin it for everyone else.

    • RBWells@lemmy.world
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      Yes it is. I have had, over my 40 years as migraineuse (they started in my teens) 5 intractable migraines. Meaning less than once every 5 years I get one that lasts days, I cannot eat or drink, just puke. I used to be able to go to my doctor and get shot up with opiates and Phenergan, so much of it, they would do one dose, come back later, another, another, another, until finally I would say “it still hurts but I don’t care” and go home nodding like a junkie, sleep and wake up with no headache, and, importantly, NO desire for more drugs.

      Now the opiates are not allowed because they didn’t work. But nothing works on the status migraine. Now they give you a cold cocktail IV of some sort of Advil and nausea medicine and it doesn’t work either, and costs $2,000 because it can only be done in the emergency room not the doctor office.

      It’s adding insult to injury. There has to be some way to make these available for acute situations at least.

      • 𝕽𝖚𝖆𝖎𝖉𝖍𝖗𝖎𝖌𝖍@midwest.social
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        I worked with a middle-aged women once who had a variety of health problems - she wheeled an oxygen tank around the office with her - who told me she got a migraine during puberty and had had it ever since.

        My wife has gotten migraine with aura since her teens, but thankfully only once every couple of months, and they tapered off to a couple times a year when she hit around 40. Her mom was opposed to allopathic medicine, so my wife never got anything stronger than sugar pills. They were bad; she’d last in bed crying and screaming, if she wasn’t at the toilet dry-heaving.

        Sometime after we married, she started trying all of the various migraine meds, like Imitrex; nothing worked reliably after the first couple of times, and now she keeps Vicodin in her purse. She uses, maybe, 20mg once every couple of months, and it mostly does like you say: she says it still hurts some, but she doesn’t care.

        I will hurt the person who tries to take that from her.

        • RBWells@lemmy.world
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          I will offer hope. Menopause, regrettably did not help, they got less intense (which I didn’t know was a thing, when the doctor used to ask I would get confused could only say worse than childbirth, they were all 11 on a scale of 10, but after menopause they were more like 6/10) and more frequent.

          But

          Menopause plus MHT (low dose of estrogen and progesterone, same amount every day) has knocked out nearly all of them.

          So if she is menopausal and still getting them, she might want to try the MHT - it’s only meant to manage symptoms (migraine could be one) not get your blood level up to any target.

          And yeah I remember how it was before I could afford any medical care, I often thought death would be relief. Migraine is the worst pain I have experienced, and I have had natural births, lost loved ones, broken bones - nothing has come close to a bad migraine. And all were bad until menopause.

            • RBWells@lemmy.world
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              It was an unexpected benefit, birth control pills made mine so much worse I was reluctant to try the MHT, but it has made a remarkable difference, I feel really good, and not dreading a migraine is probably a big part of that.

              Imitrex by injection did work for mine about 95% of the time, I am really sorry it didn’t work for your wife. It’s incredible when it works, no drugged feeling just awful feeling rush then easing of pain until no headache.

    • joel_feila@lemmy.world
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      We have never had good pain management here. Claiming babies can’t feel pain, black people hace higher pain tolerance, etc etc. then we swung into really permissive use with oxycodone for a while.

    • starman2112@sh.itjust.works
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      Yeah, I’ve dealt with massive tooth pain before. Given a choice between going through a week of that pain, and maybe killing myself with pills, I’ll take my chances with the pills.

    • Bytemeister@lemmy.world
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      Yeah, how long until this idiot cooks this liver too?

      Honestly, getting a liver transplant in a week is the most unbelievable part of this story.

          • LilB0kChoy@midwest.social
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            It really just depends on how sick you are, and where you are, at least in the US.

            For liver they use something called a MELD score. Kidney they use GFR, maybe other things, not as sure on that.

            Where matters because the US is broken into transplant regions and you can only receive an organ for a region where you’ve been listed.

            That’s why, if you have money, you could go to a couple regions and get listed, then travel wherever the first organ is available.

            In this particular case it was probably pretty important to transplant quickly, otherwise his kidneys likely would have failed.

            This man’s life drastically changed because he made a really poor decision.

            • Bytemeister@lemmy.world
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              Here’s to hoping that I never have to find out first hand.

              Just a literal Life Pro Tip for anyone still reading, sign up for organ donation. It will cost you nothing, the urban myths about hospitals harvesting the organs out of “locked in” locked in donors are total BS, but the lives you can save are very real.

    • Crankenstein@lemmy.world
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      Stupidity? The dude is living in constant pain from dental issues and was just trying to not suffer.

      Desperation is not stupidity.

      • Crankenstein@lemmy.world
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        It isn’t “natural selection” when it was caused by systemic issues preventing the man from receiving adequate dental healthcare.

      • ProgrammingSocks@pawb.social
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        People who make mistakes deserve to live too. Don’t be like that. We’ve all done stupid shit, he just happened to kill his liver with this one.

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    That guys a moron. The bottles are very very clear not to take more than the recommended dosage. Its labeled all over the bottle.

    • leisesprecher@feddit.org
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      I’m kind of pissed that such obvious and preventable idiocy leads to an almost immediate liver transplant.

      Yes, that’s just a lucky coincidence for him, but still…

    • Crankenstein@lemmy.world
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      Did you ever stop to consider that this person was in so much pain with no other alternatives that they might have done so out of desperation rather than simple ignorance?

      • NocturnalMorning@lemmy.world
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        If you’re in that much pain, you go to the hospital, you dont overdose on Tylenol. This isn’t a sympathy thing. And based on the response they gave the doctor, it was an ignorance thing.

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          I’ve been in this position before. Sent home from hospital twice to “take some paracetamol”. Third time I went in they pumped my stomach because of how much paracetamol I had taken, and finally gave me some actual painkillers.

          When you are in debilitating pain, side-effects are not something that you particularly care about.

        • Crankenstein@lemmy.world
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          Holy shit. It’s almost like there are systemic barriers that would prevent them from having access to healthcare.

          Not everyone can afford a doctor. Welcome to the reality of what people have to go through just to get through their day.

          It is entirely an empathy thing, and you lack it.

          • NocturnalMorning@lemmy.world
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            Typed a whole thing put and then deleted it. Not even going to bother. You’re making inferences you just cant make from the post. I agree, there are systemic barriers to Healthcare, this isn’t that.

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    It’s people like this who make other people think any amount of painkillers is bad, and seem to get a sense of superiority about them for never taking any.

    • ProgrammingSocks@pawb.social
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      Even a little acetaminophen makes my liver feel funny the next day. Ibuprofen actually works for pain relief for me (migraines mostly) but it can cause stomach ulcers. Painkillers are definitely not something you can just use without thinking, and daily use especially can fuck your body up, ibuprofen is also hard on your kidneys.

      Take the minimum effective dose as infrequently as possible.

      • Ledericas@lemm.ee
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        did you ever check your liver? that doesnt sound normal. with a small dose.

        nsaids can cause bleeding and ulcers if itsa high dose. its because it inhibits cox 1 and 2, for clotting, and it works on your stomach by turning off inflammation, so your stomach can combat the acid with more mucus and cell turnover(inflammation increases cell turnover), thats why h pylori is a thing.